The Command to defy the Disbelievers and Hypocrites by following the Revelation of Allah and putting One's Trust in Him
Here Allah points out something lower by referring to something higher. When He commands His servant and Messenger to do this, He is also commanding those who are lower than him, and the command is addressed to them more so. Talq bin Habib said: "Taqwa means obeying Allah in the light of the guidance of Allah and in hope of earning the reward of Allah, and refraining from disobeying Allah in the light of the guidance of Allah and fearing the punishment of Allah.''
وَلاَ تُطِعِ الْكَـفِرِينَ وَالْمُنَـفِقِينَ
(and obey not the disbelievers and the hypocrites.) means, do not listen to what they say and do not consult them.
إِنَّ اللَّهَ كَانَ عَلِيماً حَكِيماً
(Verily, Allah is Ever All-Knower, All-Wise) means, He is more deserving of your following His commandments and obeying Him, for He knows the consequences of all things and is Wise in all that He says and does. Allah says:
وَاتَّبِعْ مَا يُوحَى إِلَـيْكَ مِن رَبِّكَ
(And follow that which is revealed to you from your Lord.) meaning, of the Qur'an and Sunnah.
إِنَّ اللَّهَ كَانَ بِمَا تَعْمَلُونَ خَبِيراً
(Verily, Allah is Well-Acquainted with what you do.) means, nothing at all is hidden from Him, and put your trust in Allah, i.e., in all your affairs and situations.
وَكَفَى بِاللَّهِ وَكِيلاً
(and sufficient is Allah as a Wakil.) means, sufficient is He as a Trustee for the one who puts his trust in Him and turns to Him.